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J Neurol Sci. 2017 Sep 15;380:200-204. doi: 10.1016/j.jns.2017.07.035. Epub 2017 Jul 29.

Measurement of spontaneous blinks in patients with Parkinson's disease using a new high-speed blink analysis system.

Author information

1
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: nkimura@koto.kpu-m.ac.jp.
2
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
3
Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan.
4
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; National Center for Geriatrics and Gerontology, Aichi, Japan.
5
National Center for Geriatrics and Gerontology, Aichi, Japan.
6
Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Abstract

INTRODUCTION:

Parkinson's disease (PD) patients often have a blinking abnormality. In this study, we examined the kinematic features of spontaneous blinking in 65 PD patients and 62 healthy controls by a new research method utilizing an intelligent vision sensor camera prototype with a 1kHz sampling rate.

METHODS:

Spontaneous blinks were measured by use of a non-stress 'intelligent vision sensor' camera prototype.

RESULTS:

The mean spontaneous blink rate was 17.9 (blinks/min) in the PD patients and 15.6 in the controls (no correlation). However, there were extremely low and extremely high blink-rate groups among the PD patients. The amplitude of the closing and opening phase in the PD patients were significantly smaller than those in the controls. Small blink waves (100-200msec) prior to blink onset existed in 60% of the PD patients and in 18% of the controls.

CONCLUSION:

During spontaneous blinking the blink amplitude is decreased, and the pause between the closing and opening phase is prolonged in patients with PD. Small blink waves prior to blink onset were also characteristically found in the PD patients.

KEYWORDS:

Blink amplitude; Blink velocity; High-speed blink analyzing system; Parkinson's disease; Spontaneous blinks

PMID:
28870569
DOI:
10.1016/j.jns.2017.07.035
[Indexed for MEDLINE]

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