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Bioorg Med Chem. 2017 Oct 15;25(20):5179-5184. doi: 10.1016/j.bmc.2017.08.034. Epub 2017 Aug 22.

UPAR targeted molecular imaging of cancers with small molecule-based probes.

Author information

1
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China.
2
Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
3
Department of Cardiology, The Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
4
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address: sunyaogbasp@mail.ccnu.edu.cn.

Abstract

Molecular imaging can allow the non-invasive characterization and measurement of biological and biochemical processes at the molecular and cellular levels in living subjects. The imaging of specific molecular targets that are associated with cancers could allow for the earlier diagnosis and better treatment of diseases. Small molecule-based probes play prominent roles in biomedical research and have high clinical translation ability. Here, with an emphasis on small molecule-based probes, we review some recent developments in biomarkers, imaging techniques and multimodal imaging in molecular imaging and highlight the successful applications for molecular imaging of cancers.

KEYWORDS:

AE105; Molecular imaging; Multimodal imaging; NIR-II; Small molecule-based probes; UPAR

PMID:
28869084
DOI:
10.1016/j.bmc.2017.08.034
[Indexed for MEDLINE]

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