Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae)

Abdou Tchoukoua; Turibio Kuiate Tabopda; Ingrid Konga Simo; Shota Uesugi; Misa Ohno; Ken-Ichi Kimura; Eunsang Kwon; Hiroyuki Momma; Yoshihito Shiono; Bonaventure Tchaleu Ngadjui

doi:10.1080/14786419.2017.1371156

Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae)

Nat Prod Res. 2018 Apr;32(8):924-932. doi: 10.1080/14786419.2017.1371156. Epub 2017 Sep 4.

Authors

Abdou Tchoukoua^{1

2}, Turibio Kuiate Tabopda¹, Ingrid Konga Simo³, Shota Uesugi⁴, Misa Ohno⁴, Ken-Ichi Kimura^{4

5}, Eunsang Kwon⁶, Hiroyuki Momma⁶, Yoshihito Shiono², Bonaventure Tchaleu Ngadjui^{1

7}

Affiliations

¹ a Department of Organic Chemistry , University of Yaounde 1 , Yaounde , Cameroon.
² b Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
³ c Department of Chemistry , University of Dschang , Dschang , Cameroon.
⁴ d Laboratory of Chemical Biology , The United Graduate School of Agricultural Sciences, Iwate University , Morioka , Japan.
⁵ e Graduate School of Agriculture , Iwate University , Morioka , Japan.
⁶ f Research and Analytical Center for Giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
⁷ g Faculty of Medicine and Biomedical Sciences, Department of Medicine and Traditional Pharmacopoeia , University of Yaounde 1 , Yaounde , Cameroon.

PMID: 28868920
DOI: 10.1080/14786419.2017.1371156

Abstract

Two new triterpene saponins, albidosides H (1) and I (2), along with the three known saponins were isolated from the barks of Acacia albida. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies and mass spectrometry. Albidosides H (1) and I (2) were assayed for their cytotoxicity against HeLa and HL60 cells using MTT method.

Keywords: 13C; 1H; Acacia albida; Mimosaceae; NMR; Triterpene saponins; cytotoxicity.

MeSH terms

Acacia / chemistry*
Drug Screening Assays, Antitumor / methods
HL-60 Cells
HeLa Cells
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Oleanolic Acid / analogs & derivatives
Plant Bark / chemistry
Saponins / chemistry*
Saponins / pharmacology
Triterpenes / chemistry*
Triterpenes / pharmacology

Substances

Saponins
Triterpenes
albidoside
Oleanolic Acid