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Mol Cell Oncol. 2017 Jun 19;4(4):e1342747. doi: 10.1080/23723556.2017.1342747. eCollection 2017.

SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer.

Author information

1
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2
Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
4
Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University, St. Louis, MO, USA.

Abstract

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

KEYWORDS:

BAF180; Clear Cell Kidney Cancer Mouse Model; Genomic Biomarkers; MTOR; PBRM1; SWI/SNF Chromatin Remodeling Tumor Suppressor Gene; VHL

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