Recent advances in understanding and treating chronic granulomatous disease

F1000Res. 2017 Aug 11:6:1427. doi: 10.12688/f1000research.11789.1. eCollection 2017.

Abstract

A number of recent advances have been made in the epidemiology and treatment of chronic granulomatous disease. Several reports from developing regions describe the presentations and progress of local populations, highlighting complications due to Bacillus Calmette-Guérin vaccination. A number of new reports describe complications of chronic granulomatous disease in adult patients, as more survivors reach adulthood. The complications experienced by X-linked carriers are particularly highlighted in three new reports, confirming that infection and inflammatory or autoimmune conditions are more common and severe than previously recognised. Finally, definitive treatment with haematopoietic stem cell transplantation and gene therapy is reviewed.

Keywords: X-linked carrier disease; chronic granulomatous disease; gene therapy; haematopoietic stem cell transplantation; inflammatory bowel disease.

Publication types

  • Review

Grants and funding

The author(s) declared that no grants were involved in supporting this work.