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Cardiol Res. 2017 Aug;8(4):139-142. doi: 10.14740/cr578w. Epub 2017 Aug 23.

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM.

Author information

1
Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, USA.
2
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, CCAH Room 258, One Shields Avenue, Davis, CA, USA.
3
Department of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

Abstract

Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from in vitro and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients.

KEYWORDS:

Arterial thromboembolism; Cats; Congestive heart failure; Hypertrophic cardiomyopathy; Natural animal model

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