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Chem Pharm Bull (Tokyo). 2017;65(9):840-847. doi: 10.1248/cpb.c17-00314.

Four New Lignans and IL-2 Inhibitors from Magnoliae Flos.

Author information

1
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University.
2
College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu.
3
School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology.

Abstract

Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7'-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher's esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11-14 reduced IL-2 expression in a dose-dependent manner.

KEYWORDS:

Magnolia biondii PAMP.; Magnoliaceae; anti-allergy; interleukin-2; lignan

PMID:
28867711
DOI:
10.1248/cpb.c17-00314
[Indexed for MEDLINE]
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