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Neuron. 2017 Sep 13;95(6):1319-1333.e5. doi: 10.1016/j.neuron.2017.08.023. Epub 2017 Aug 31.

Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.

Author information

1
Neurobiology Section, Division of Biological Sciences and Center for Neural Circuits and Behavior, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA 92093-0357, USA; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093-0603, USA. Electronic address: ddulcis@ucsd.edu.
2
Neurobiology Section, Division of Biological Sciences and Center for Neural Circuits and Behavior, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA 92093-0357, USA.
3
Neurobiology Section, Division of Biological Sciences and Center for Neural Circuits and Behavior, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA 92093-0357, USA; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093-0603, USA.
4
Department of Neuroscience, University of California San Diego, La Jolla, CA 92093-0649, USA.

Abstract

Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons during development. We show that protracted exposure to kin or non-kin odorants changes the number of dopamine (DA)- or gamma aminobutyric acid (GABA)-expressing neurons, with corresponding changes in attraction/aversion behavior. Changing the relative number of dopaminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor antagonists alters kinship preference. We then isolate AOB microRNAs (miRs) differentially regulated across these conditions. Inhibition of miR-375 and miR-200b reveals that they target Pax6 and Bcl11b to regulate the dopaminergic and GABAergic phenotypes. The results illuminate the role of NT switching governing experience-dependent social preference. VIDEO ABSTRACT.

KEYWORDS:

GABA; Xenopus larvae; accessory olfactory bulb; dopamine; miR-200b; miR-375; microRNA; neurotransmitter switching; odorants; social preference

PMID:
28867550
PMCID:
PMC5893310
DOI:
10.1016/j.neuron.2017.08.023
[Indexed for MEDLINE]
Free PMC Article

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