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J Pediatr. 2017 Nov;190:275-279. doi: 10.1016/j.jpeds.2017.06.055. Epub 2017 Sep 1.

Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository.

Author information

1
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA. Electronic address: Joy.Wan@uphs.upenn.edu.
2
Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI.
3
Pediatric Dermatology Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
4
Vascular Anomalies Program, Lenox Hill Hospital, Northwell Health, New York, NY.
5
Department of Dermatology, University of Rochester Medical Center, Rochester, NY.
6
Department of Dermatology, Columbia University, New York, NY; Department of Pediatrics, Columbia University, New York, NY.
7
Kuchnir Dermatology & Dermatologic Surgery, Framingham and Milford, MA.
8
Department of Dermatology, School of Medicine, Indiana University, Indianapolis, IN.
9
Department of Dermatology, Oregon Health & Science University, Portland, OR; Department of Pediatrics, Oregon Health & Science University, Portland, OR.
10
Department of Dermatology, University of California San Francisco, San Francisco, CA.
11
Department of Dermatology, Texas Children's/Baylor College of Medicine, Houston, TX.
12
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
13
Department of Pediatric Dermatology, Sydney Children's Hospital School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
14
Departments of Dermatology and Pediatrics, Section of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, WI.

Abstract

The cause of PHACE syndrome is unknown. In a study of 218 patients, we examined potential prenatal risk factors for PHACE syndrome. Rates of pre-eclampsia and placenta previa in affected individuals were significantly greater than in the general population. No significant risk factor differences were detected between male and female subjects.

KEYWORDS:

disease pathogenesis; hemangioma; perinatal risk factors

PMID:
28867065
PMCID:
PMC5690843
DOI:
10.1016/j.jpeds.2017.06.055
[Indexed for MEDLINE]
Free PMC Article

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