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J Clin Hypertens (Greenwich). 2017 Nov;19(11):1152-1161. doi: 10.1111/jch.13062. Epub 2017 Sep 3.

The association between insulin resistance and atrial fibrillation: A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial).

Author information

1
Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.
2
George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
3
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA.
4
Department of Nephrology, The Second Xiangya Hospital, Changsha, China.
5
Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
6
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
7
Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA.
8
Department of Medicine, Stanford University, Stanford, CA, USA.
9
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
10
Division of General Internal Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
11
Baylor College of Medicine, Houston, TX, USA.
12
Division of Nephrology and Hypertension, Vanderbilt University, Nashville, TN, USA.
13
Division of Hypertension and Clinical Pharmacology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
14
Division of General Internal Medicine, University of Miami, Miami, FL, USA.
15
Division of Cardiothoracic and Abdominal Transplant Surgery, Columbia University, New York, NY, USA.

Abstract

It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55%, while 8.2% of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non-chronic kidney disease subgroups. Age, race, history of cardiovascular diseases, decreased triglycerides, decreased pulse pressure, and albuminuria remained significantly associated with AF risk. In contrast to the general population, MetS was not associated with AF in the older population with increased cardiovascular risk studied in SPRINT.

KEYWORDS:

chronic renal failure; insulin resistance; metabolic syndrome

PMID:
28866864
DOI:
10.1111/jch.13062
[Indexed for MEDLINE]
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