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Ann Allergy Asthma Immunol. 2017 Nov;119(5):446-451. doi: 10.1016/j.anai.2017.07.019. Epub 2017 Aug 31.

Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis.

Author information

1
Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy. Electronic address: saramanti@hotmail.it.
2
Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy.
3
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
4
Department of Women, Child and General and Specialist Surgery, Second University of Naples, Naples, Italy.
5
Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
6
Department of Pediatrics, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, France.

Abstract

BACKGROUND:

Although mutations in the filaggrin (FLG) gene have been reported to predispose patients with atopic dermatitis (AD) skin infection susceptibility, to date, the data reported in the literature are still controversial.

OBJECTIVE:

To evaluate the role of FLG polymorphisms expression and risk of developing a concomitant Molluscum contagiosum sustained skin infection in the pediatric population with AD.

METHODS:

A total of 100 children with AD and 97 healthy children were enrolled. AD was diagnosed and assessed according to the validated European Task Force on Atopic Dermatitis. DNA samples of patients were analyzed for allelic variants in the promoter and coding exon of FLG. Genotyping was performed with polymerase chain reaction amplification and direct sequencing.

RESULTS:

Sixteen FLG variants have been detected in 29% of patients with AD: 2 synonymous (rs79808464 and rs116222149), 12 missense (rs11584340, rs113136594, rs145828067, rs374910442, rs747005144, rs145627745, rs144209313, rs74129443, rs192455877, rs150957860, rs138055273, rs147472105), 1 stop gained (rs183942200), and 1 frameshift (rs 558269137). In contrast, only 13% of the control group reported FLG mutations (22 heterozygous variants). In addition, the age at disease onset correlated significantly with FLG variants (P < .001). In addition, the AD with FLG gene variants (rs145627745, rs79808464, rs150957860, rs145828067, rs747005144, rs374910442, rs138055273, rs183942200, rs11584340, and rs113136594) reported moderate to severe Scoring Atopic Dermatitis scores. Finally, the AD group and the AD plus M contagiosum skin infection group had a significant association with FLG mutations when compared with the control group (P < .01).

CONCLUSION:

FLG mutations are associated with early onset of AD, more severe clinical course of disease, and a significantly increased risk of M contagiosum sustained skin infection.

PMID:
28866311
DOI:
10.1016/j.anai.2017.07.019
[Indexed for MEDLINE]

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