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Eur J Cancer. 2017 Oct;84:335-353. doi: 10.1016/j.ejca.2017.07.015. Epub 2017 Sep 1.

Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study.

Collaborators (139)

Hackl M12, Zielonke N12, Van Eycken E13, Henau K13, Valerianova Z14, Dimitrova N14, Sekerija M15, Dušek L16, Zvolský M16, Mägi M17, Aareleid T18, Malila N19, Seppä K19, Bouvier AM20, Faivre J20, Bossard N21, Uhry Z22, Colonna M23, Stabenow R24, Luttmann S25, Eberle A25, Brenner H26, Nennecke A27, Engel J28, Schubert-Fritschle G28, Heidrich J29, Holleczek B30, Katalinic A31, Clough-Gorr K32, Mazzoleni G33, Bulatko A33, Buzzoni C34, Giacomin A35, Ferretti S36, Barchielli A37, Caldarella A37, Gatta G38, Sant M38, Amash H38, Amati C38, Baili P38, Berrino F38, Bonfarnuzzo S38, Botta L38, Capocaccia R38, Di Salvo F38, Foschi R38, Margutti C38, Meneghini E38, Minicozzi P38, Trama A38, Serraino D39, Maso LD39, De Angelis R40, Caldora M40, Carrani E40, Francisci S40, Knijn A40, Mallone S40, Pierannunzio D40, Roazzi P40, Rossi S40, Santaquilani M40, Tavilla A40, Pannozzo F41, Natali M41, Filiberti RA42, Marani E42, Autelitano M43, Spagnoli G44, Cirilli C44, Fusco M45, Vitale MF45, Traina A46, Staiti R46, Vitale F47, Cusimano R47, Michiara M48, Tumino R49, Falcini F50, Caiazzo AL51, Maspero S52, Fanetti AC52, Zanetti R53, Rosso S53, Rugge M54, Tognazzo S54, Pildava S55, Smailyte G56, Johannesen TB57, Rachtan J58, Góźdź S59, Mężyk R59, Błaszczyk J60, Kępska K60, Bielska-Lasota M61, Forjaz de Lacerda G62, Bento MJ63, Antunes L63, Miranda A64, Mayer-da-Silva A64, Safaei Diba C65, Primic-Zakelj M66, Almar E67, Mateos A67, Lopez de Munain A68, Larrañaga N68, Torrella-Ramos A69, Díaz García JM70, Jimenez-Chillaron R70, Marcos-Gragera R71, Vilardell L71, Moreno-Iribas C72, Ardanaz E72, Lambe M73, Mousavi M74, Bouchardy C75, Usel M75, Ess SM76, Frick H76, Lorez M77, Ess SM78, Herrmann C78, Bordoni A79, Spitale A79, Konzelmann I80, Visser O81, Damhuis R81, Otter R81, Coleman M82, Allemani C82, Rachet B82, Rashbass J83, Broggio J83, Verne J83, Gavin A84, Fitzpatrick D84, Huws DW85, White C85.

Author information

1
Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: pamela.minicozzi@istitutotumori.mi.it.
2
Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn, Estonia.
3
Andalusian School of Public Health, Instituto de Investigación Biosanitaria de Granada (ibs.Granada), Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP), Madrid, Spain.
4
Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
5
National Cancer Registry, Cork Airport Business Park, Cork, Ireland.
6
Epidemiology Unit and Girona Cancer Registry, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute, Girona, Spain.
7
National Hospital of Oncology, Bulgarian National Cancer Registry, Sofia, Bulgaria.
8
Department of Registration, Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands.
9
Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
10
National Centre for Prevention of Disease and Promotion of Health, Istituto Superiore Sanità, Rome, Italy.
11
Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
12
Austrian CR, Austria.
13
Belgian CR, Belgium.
14
Bulgarian CR, Bulgaria.
15
Croatian CR, Croatia.
16
Czech National CR, Czech Republic.
17
Estonian CR, Estonia.
18
National Institute for Health Development, Estonia.
19
Finnish CR, Finland.
20
Côte d'Or Digestive Tract Registry, Burgundy, France.
21
Hospices Civils de Lyon, France.
22
Hospices Civils de Lyon, Institut de Veille Sanitaire, France.
23
Isère CR, France.
24
Berlin CR, Germany; Brandenburg CR, Germany; Mecklenburg-West Pomerania CR, Germany; Saxony CR, Germany; Saxony-Anhalt CR, Germany; Thüringen CR, Germany.
25
Bremen CR, Leibniz Institute for Prevention Research and Epidemiology, Germany.
26
German Cancer Research Center, Germany.
27
Hamburg CR, Germany.
28
Munich CR, Germany.
29
North, Rhine-Westphalia CR, Germany.
30
Saarland CR, Germany.
31
Schleswig-Holstein CR, Germany.
32
National Cancer Registry Ireland, Ireland.
33
Alto Adige CR, Italy.
34
Associazione Italiana Registri Tumore, Italy.
35
Biella CR, Italy.
36
Ferrara CR, Italy.
37
Firenze- Prato CR, Italy.
38
Fondazione Istituto, Nazionale dei Tumori, Milan, Italy.
39
Friuli Venezia Giulia CR, CRO Aviano National Cancer, Institute, Italy.
40
Istituto Superiore di Sanità, Rome, Italy.
41
Latina CR, Italy.
42
Liguria CR, IRCCS AOU SM-IST, Italy.
43
Milano CR, Italy.
44
Modena CR, Italy.
45
Napoli 3 South CR, Italy.
46
Palermo Breast CR, Italy.
47
Palermo CR, Italy.
48
Parma CR, Italy.
49
Ragusa CR, Italy.
50
Romagna CR, IRCCS AUSLIRST Meldola, Italy.
51
Salerno CR, Italy.
52
Sondrio CR, Italy.
53
Torino CR, Italy.
54
Veneto CR, Italy.
55
Latvian CR, Latvia.
56
Lithuanian CR, Lithuania.
57
Norwegian CR, Norway.
58
Cracow CR, Poland.
59
Kielce CR, Poland.
60
Lower Silesia CR, Wroclaw, Poland.
61
National Institute of Public Health-NIH, Warszawa, Poland.
62
Açores CR, Portugal.
63
Northern Portugal CR, Portugal.
64
Southern Portugal CR, Portugal.
65
Slovakian National CR, Slovakia.
66
Cancer Registry of Republic of Slovenia, Slovenia.
67
Albacete, Castilla-La Mancha CR, Spain.
68
Basque Country CR, Spain.
69
Castellón-Valencia CR, breast, Spain.
70
Cuenca CR, Spain.
71
Girona CR, Spain.
72
Navarra CR, CIBERESP, Spain.
73
Regionalt Cancercentrum and Karolinska Institutet, Sweden.
74
Basel CR, Switzerland.
75
Geneva CR, Switzerland.
76
Grisons-Glarus CR, Switzerland.
77
NICER, Switzerland.
78
St. Gallen CR, Switzerland.
79
Ticino CR, Switzerland.
80
Valais CR, Switzerland.
81
The Netherlands CR, The Netherlands.
82
London School of Hygiene and Tropical Medicine, UK-England.
83
Public Health England, UK-England.
84
Northern Ireland CR, UK-Northern Ireland.
85
Welsh Cancer Intelligence and Surveillance Unit, UK-Wales.

Abstract

BACKGROUND:

Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis-an essential information item collected by CRs-has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data quality.

DATA AND METHODS:

Sixty-two CRs sent stage (as TNM, condensed TNM or extent of disease) for 15 cancers diagnosed in 2000-2007. We assessed the quality, partly by comparing stage according to the three systems. We also developed procedures to reconstruct stage (categories: local, regional, metastatic and unknown) using information from all three systems, thus minimising the amount of missing information.

RESULTS:

Moderate-to-excellent stage concordance was found for practically all 24 CRs, for which it was possible to compare at least two staging systems. However, since stage was often incorrectly assigned, and information on the presence/absence of metastases was often lacking, data on only 7/15 cancers from 34/62 CRs (15 countries) were of sufficient quality for further analysis. Cases diagnosed ≥70 years had more advanced (or lacking) stage- and worse stage-specific survival than those <70 years.

CONCLUSIONS:

Many European CRs collect and record reasonably accurate stage information. Others have difficulties. Both the completeness of primary data and the accuracy of stage coding need to be improved in order for CRs to fulfil their expanding roles in cancer control. We propose our stage reconstruction/checking procedures as a means of fully exploiting the stage information provided by EUROCARE CRs. More advanced (or lacking) stage at diagnosis plus poorer stage-specific survival in the elderly are worrying.

KEYWORDS:

Cancer registries; Data quality; Stage at diagnosis; Survival

PMID:
28865261
DOI:
10.1016/j.ejca.2017.07.015
[Indexed for MEDLINE]

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