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Adv Exp Med Biol. 2017;1006:281-290. doi: 10.1007/978-4-431-56550-5_16.

Drebrin Regulation of Calcium Signaling in Immune Cells.

Author information

1
Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.
2
Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA. averyaugust@cornell.edu.

Abstract

Store-operated Ca2+ channels are plasma membrane channels that are activated by depletion of intracellular Ca2+ stores, resulting in an increase in intracellular Ca2+; however, little is known about their regulation. Our work has shown that the immunosuppressant compound BTP2, which blocks Ca2+ influx into cells, interacts with the actin-reorganizing protein, drebrin. Here we review the role of drebrin in the regulation of calcium signaling, with a focus on immune cells.

KEYWORDS:

Acute IgE challenge; BTP2; FcεRI-mediated actin organization; Filopodia extension; Jurkat T cells; Store-operated Ca2+ channel

PMID:
28865026
DOI:
10.1007/978-4-431-56550-5_16
[Indexed for MEDLINE]

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