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J Am Soc Nephrol. 2017 Nov;28(11):3166-3174. doi: 10.1681/ASN.2017020143. Epub 2017 Sep 1.

The Evolving Complexity of the Podocyte Cytoskeleton.

Schell C1,2, Huber TB3,4,5.

Author information

1
Institute of Surgical Pathology and.
2
Department of Medicine IV, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
3
Department of Medicine IV, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; t.huber@uke.de.
4
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and.
5
BIOSS Centre for Biological Signalling Studies and Center for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University, Freiburg, Germany.

Abstract

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.

KEYWORDS:

cytoskeleton; glomerular disease; nephrotic syndrome; podocyte

PMID:
28864466
PMCID:
PMC5661293
DOI:
10.1681/ASN.2017020143
[Indexed for MEDLINE]
Free PMC Article

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