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J Am Acad Dermatol. 2017 Nov;77(5):938-945.e4. doi: 10.1016/j.jaad.2017.06.149. Epub 2017 Aug 29.

A meta-analysis of nevus-associated melanoma: Prevalence and practical implications.

Author information

1
Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy.
2
First Department of Dermatology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
3
Dermatology Unit, University of Campania, Naples, Italy.
4
Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy; Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: longo.caterina@gmail.com.

Abstract

The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I2 = 98%).

KEYWORDS:

dysplastic nevus; melanoma; meta-analysis; nevus-associated; prevalence; thickness

PMID:
28864306
DOI:
10.1016/j.jaad.2017.06.149
[Indexed for MEDLINE]

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