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J Ethnopharmacol. 2018 Jan 10;210:296-310. doi: 10.1016/j.jep.2017.08.035. Epub 2017 Aug 31.

Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases.

Author information

1
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil 57000, Malaysia.
2
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil 57000, Malaysia. Electronic address: srinivasan_ramamurthy@imu.edu.my.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

The compound epigallocatechin-3-gallate (EGCG), the major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has shown numerous cardiovascular health promoting activity through modulating various pathways. However, molecular understanding of the cardiovascular protective role of EGCG has not been reported.

AIM OF THE REVIEW:

This review aims to compile the preclinical and clinical studies that had been done on EGCG to investigate its protective effect on cardiovascular and metabolic diseases in order to provide a systematic guidance for future research.

MATERIALS AND METHODS:

Research papers related to EGCG were obtained from the major scientific databases, for example, Science direct, PubMed, NCBI, Springer and Google scholar, from 1995 to 2017.

RESULTS:

EGCG was found to exhibit a wide range of therapeutic properties including anti-atherosclerosis, anti-cardiac hypertrophy, anti-myocardial infarction, anti-diabetes, anti-inflammatory and antioxidant. These therapeutic effects are mainly associated with the inhibition of LDL cholesterol (anti-atherosclerosis), inhibition of NF-κB (anti-cardiac hypertrophy), inhibition of MPO activity (anti-myocardial infarction), reduction in plasma glucose and glycated haemoglobin level (anti-diabetes), reduction of inflammatory markers (anti-inflammatory) and the inhibition of ROS generation (antioxidant).

CONCLUSION:

EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases was discussed.

KEYWORDS:

Anti-inflammatory; Antioxidant; Atherosclerosis; Diabetes; EGCG; Heart failure

PMID:
28864169
DOI:
10.1016/j.jep.2017.08.035
[Indexed for MEDLINE]

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