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Fitoterapia. 2017 Oct;122:90-94. doi: 10.1016/j.fitote.2017.08.016. Epub 2017 Aug 31.

Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity.

Author information

1
Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.
2
Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Hungary.
3
Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6720 Szeged, Hungary; Interdisciplinary Centre of Natural Products, University of Szeged, 6720 Szeged, Hungary.
4
Department of Botany, University of West Hungary, 9200 Mosonmagyaróvár, Hungary.
5
Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary; Interdisciplinary Centre of Natural Products, University of Szeged, 6720 Szeged, Hungary.
6
Department of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary. Electronic address: vasasa@pharmacognosy.hu.

Abstract

The present study aimed at the phytochemical and pharmacological investigation of Sideritis montana L. (Lamiaceae). Two new abietane diterpenes [sideritins A (1) and B (2)] were isolated from the methanol extract of the plant. Six known compounds [pomiferin E (3), 9α,13α-epi-dioxyabiet-8(14)-en-18-ol (4), paulownin (5), 6-methoxysakuranetin (6), 3-oxo-α-ionol (7) and 4-allyl-2,6-dimethoxyphenol glucoside (8)] were also obtained from the plant. The structures were determined by means of HREIMS and NMR experiments. The antiproliferative effect of the isolated compounds was investigated on human cancer cell lines (HeLa, SiHa and C33A) at 10 and 30μM concentrations, using the MTT assay. The results demonstrated that pomiferin E (3) and 6-methoxysakuranetin (6) displayed considerable activity [inhibition (%)±SEM: 46.93±2.35 on HeLa (pomiferin E), and 51.52±2.45 on C33A (6-methoxysakuranetin)] at 30μM concentration.

KEYWORDS:

Antiproliferative activity; Diterpenoids; Flavonoid; Lamiaceae; Sideritis montana

PMID:
28864041
DOI:
10.1016/j.fitote.2017.08.016
[Indexed for MEDLINE]

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