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Cytokine. 2018 Feb;102:163-167. doi: 10.1016/j.cyto.2017.08.012. Epub 2017 Aug 30.

Association between maternal circulating IL-27 levels and preeclampsia.

Author information

1
Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran; Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
2
Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran.
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. Electronic address: forghani_f@yahoo.com.
4
Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
5
Department of Obstetrics and Gynecology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
6
Department of Clinical Biochemistry, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

In this study, we investigated the relationship between serum level of IL-27 with preeclampsia and its severity. Fifty-six preeclamptic, 21 health pregnant and 20 health nonpregnant women formed the study group. The levels of IL-27 in maternal circulation were determined by ELISA. IL-27 serum levels were found to be elevated in healthy pregnant and preeclamptic groups as compared to non-pregnant women, this increase was significant in preeclamptic cases (p=0.0004). Moreover, a significant difference of IL-27 serum level was observed between groups and the healthy pregnant controls, (p=0.0095). Notably, the level of IL-27 was considerably elevated in women with severe preeclampsia, but not with mild preeclampsia as compared with healthy pregnant women (p=0.0056, p=0.0964, respectively). Furthermore, IL-27 serum levels were significantly differences in early onset and late onset sever preeclampsia than in gestation matched healthy pregnancies (p=0.0376, p=0.0085, respectively). In conclusion, our results suggest IL-27 might be a useful biomarker for disease severity in preeclampsia.

KEYWORDS:

Inflammation; Interleukin-27 (IL-27); Preeclampsia; Pregnancy

PMID:
28863926
DOI:
10.1016/j.cyto.2017.08.012
[Indexed for MEDLINE]

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