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J Affect Disord. 2018 Jan 1;225:466-473. doi: 10.1016/j.jad.2017.08.036. Epub 2017 Aug 18.

Sensory profiles as potential mediators of the association between hypomania and hopelessness in 488 major affective outpatients.

Author information

1
Department of Occupational Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Israel.
2
Department of Psychiatry and Psychotherapy, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary; MTA-SE Neuropsychopharmacology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary; Department of Pharmacodynamics, Semmelweis University, Hungary.
3
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy.
4
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Italy.
5
Department of Psychiatry and Psychotherapy, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary.
6
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. Electronic address: gianluca.serafini@unige.it.

Abstract

INTRODUCTION:

Extreme sensory processing patterns may contribute to the pathophysiology of major affective disorders. We aimed to examine whether significant correlations exist between sensory profiles, hypomania, self-reported depression, and hopelessness and whether sensory profiles may be potential mediators of the association between hypomania and depression/hopelessness.

METHODS:

The sample consisted of 488 euthymic affective disorder patients of which 283 diagnosed with unipolar and 162 with bipolar disorder with an age ranging from 18 to 65 years (mean = 47.82 ± 11.67).

RESULTS:

Lower registration of sensory input and sensory sensitivity significantly correlated with elevated self-reported depression, hopelessness, and irritable/risk-taking hypomania while sensation seeking and avoiding significantly correlated with elevated depression and hopelessness but not with irritable/risk-taking hypomania. Moreover, individuals with lower ability to register sensory input and higher hypomania showed higher self-reported depression than those with good registration of sensory information. According to SEM analyses, there was both a direct/indirect effect of irritable/risk-taking on depression-hopelessness with the mediation model explaining 48% of the variance in depression-hopelessness.

LIMITATIONS:

The relatively small sample size and the cross-sectional nature of the study design do not allow the generalization of the main findings.

CONCLUSION:

Low registration was associated with enhanced depressed mood and hopelessness while sensory seeking may be considered a resilient factor.

KEYWORDS:

Hopelessness; Hypomania; Major affective disorders; Self-reported depression; Sensory processing patterns

PMID:
28863299
DOI:
10.1016/j.jad.2017.08.036
[Indexed for MEDLINE]

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