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J Synchrotron Radiat. 2017 Sep 1;24(Pt 5):991-999. doi: 10.1107/S1600577517009572. Epub 2017 Aug 7.

Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots.

Author information

1
UMR S1155, INSERM/UPMC, 4 Rue de la Chine, 75970 Paris Cedex 20, France.
2
Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette, France.
3
Laboratoire Chimie de la Matière Condensée de Paris, UMR UPMC College de France - CNRS 7574, Université Pierre et Marie Curie (Paris 6), 4 Place Jussieu, 75252 Paris, France.
4
Department of Chemistry, University of Liège, B4000 Liège, Belgium.
5
Karlsruhe Institute of Technology, Institute of Nanotechnology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

Abstract

The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift. Moreover, numerous X-ray absorption near-edge structure spectra, which are beam-time-consuming taking into account the low concentration of these theranostic vectors, were collected.

KEYWORDS:

Flyscan method; X-ray fluorescence; XANES; gold-cluster-enriched mesoporous silica nanospheres; theranostic vectors

PMID:
28862621
DOI:
10.1107/S1600577517009572

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