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J Cancer Res Ther. 2017 Jul-Sep;13(3):412-418. doi: 10.4103/0973-1482.176178.

Spindle cell lesions: A review on immunohistochemical markers.

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Department of Oral and Maxillofacial Pathology and Microbiology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.


The intriguing array of spindle cell lesions occurring, especially in the head and neck region, poses a critical diagnostic challenge not only to the histopathologist but also ultimately to the clinicians for planning an appropriate treatment protocol. Overlapping spectrum of clinico-radiographic and microscopic features further compounds this problem. In such situations, the aid of ancillary techniques such as immunohistochemistry (IHC) is sought to clinch the diagnosis. This study aims to review the spindle cell neoplasms of the oral cavity with emphasis on IHC.

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