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Neurochem Res. 2017 Dec;42(12):3390-3400. doi: 10.1007/s11064-017-2379-5. Epub 2017 Aug 31.

Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson's Disease Are Related to Its Anti-Inflammatory Effects.

Author information

1
Department of Physiology and Pharmacology, Faculty of Medicine of the Federal University of Ceará (UFC), Rua Cel. Nunes de Melo, 1000, Fortaleza, CEP 60416-000, Ceará, Brazil.
2
G & F Spirulina do Brasil Ltda., Fortaleza, Brazil.
3
Department of Physiology and Pharmacology, Faculty of Medicine of the Federal University of Ceará (UFC), Rua Cel. Nunes de Melo, 1000, Fortaleza, CEP 60416-000, Ceará, Brazil. gbviana@live.com.
4
Department of Biophysiology, Faculty of Medicine Estácio of Juazeiro do Norte (Estácio/FMJ), Avenida Tenente Raimundo Rocha, 555, Juazeiro do Norte, 63040-360, Ceará, Brazil. gbviana@live.com.
5
G & F Spirulina do Brasil Ltda., Fortaleza, Brazil. gbviana@live.com.

Abstract

Spirulina platensis (SPI) is a cyanobacterium, presenting anti-inflammatory and antioxidant actions. Considering the importance of inflammation and oxidative stress in Parkinson's disease (PD), SPI neuroprotective effects were evaluated in a model of PD. Male Wistar rats were divided into: sham-operated (SO), untreated 6-OHDA and 6-OHDA treated with SPI (25 and 50 mg/kg, p.o.). The 6-OHDA was injected into the right striata and SPI treatments started 24 h later for 2 weeks. The SO and untreated 6-OHDA-lesioned groups were administered with distilled water, for the same period. Afterwards, the animals were subjected to the apomorphine-induced rotational test and euthanized for striatal measurements of DA and DOPAC, nitrite and TBARS and immunohistochemistry assays for TH, DAT, iNOS and COX-2. SPI reduced the apomorphine-induced rotational behavior, DA and DOPAC depletions and nitrite and TBARS increases, at its high dose. Furthermore, TH and DAT immunoreactivities in the lesioned striatum of the untreated 6-OHDA-lesioned group were attenuated by SPI. Similarly, immunoreactivities for iNOS and COX-2 were also decreased after SPI treatments. In conclusion, we showed that behavioral and neurochemical alterations in hemiparkinsonian rats were partly reversed by SPI, characterizing the neuroprotective potential of Spirulina and stimulating translational studies focusing on its use as an alternative treatment for PD.

KEYWORDS:

Neuroinflammation; Oxidative stress; Parkinson’s disease; Spirulina platensis

PMID:
28861668
DOI:
10.1007/s11064-017-2379-5
[Indexed for MEDLINE]

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