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Chem Commun (Camb). 2017 Sep 12;53(73):10228-10231. doi: 10.1039/c7cc05570f.

Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis.

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State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.


The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps offers a novel and convenient approach to selective reduction of carboxylic acids to aldehydes. The method also features mild conditions, high yields, broad substrate scope, and good functional group tolerance, such as alkyne, ester, ketone, amide and amine groups.

[Indexed for MEDLINE]

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