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Korean J Radiol. 2017 Sep-Oct;18(5):821-827. doi: 10.3348/kjr.2017.18.5.821. Epub 2017 Jul 17.

Photoacoustic Imaging for Differential Diagnosis of Benign Polyps versus Malignant Polyps of the Gallbladder: A Preliminary Study.

Author information

1
Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 03080, Korea.
2
Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 03080, Korea.
3
Sogang Institute of Advanced Technology, Sogang University, Seoul 04107, Korea.
4
Department of Biomedical Engineering, Sogang University, Seoul 04107, Korea.
5
Department of Electronic Engineering, Sogang University, Seoul 04107, Korea.

Abstract

OBJECTIVE:

To investigate the feasibility of ex vivo multispectral photoacoustic (PA) imaging in differentiating cholesterol versus neoplastic polyps, and benign versus malignant polyps, of the gallbladder.

MATERIALS AND METHODS:

A total of 38 surgically confirmed gallbladder polyps (24 cholesterol polyps, 4 adenomas, and 10 adenocarcinomas) from 38 patients were prospectively included in this study. The surgical specimens were set on a gel pad immersed in a saline-filled container. The PA intensities of polyps were then measured, using two separate wavelength intervals (421-647 nm and 692-917 nm). Mann-Whitney U test was performed for the comparison of normalized PA intensities between the cholesterol and neoplastic polyps, and between the benign and malignant polyps. Kruskal-Wallis test was conducted for the comparison of normalized PA intensities among the cholesterol polyps, adenomas, and adenocarcinomas.

RESULTS:

A significant difference was observed in the normalized PA intensities between the cholesterol and neoplastic polyps at 459 nm (median, 1.00 vs. 0.73; p = 0.032). Comparing the benign and malignant polyps, there were significant differences in the normalized PA intensities at 765 nm (median, 0.67 vs. 0.78; p = 0.013), 787 nm (median, 0.65 vs. 0.77; p = 0.034), and 853 nm (median, 0.59 vs. 0.85; p = 0.028). The comparison of the normalized PA intensities among cholesterol polyps, adenomas, and adenocarcinomas demonstrated marginally significant differences at 765 nm (median, 0.67 vs. 0.66 vs. 0.78, respectively; p = 0.049).

CONCLUSION:

These preliminary results indicate that benign versus malignant gallbladder polyps might exhibit different spectral patterns on multispectral PA imaging.

KEYWORDS:

Gallbladder neoplasm; Gallbladder polyp; Neoplastic polyp; Photoacoustic technique

PMID:
28860899
PMCID:
PMC5552465
DOI:
10.3348/kjr.2017.18.5.821
[Indexed for MEDLINE]
Free PMC Article

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