Send to

Choose Destination
Neuropsychiatr Dis Treat. 2017 Aug 16;13:2185-2191. doi: 10.2147/NDT.S141555. eCollection 2017.

Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study.

Author information

Division of Cognitive Behavioral Science, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Chiba-shi, Chiba.
Department of Psychiatry, Chibaken Saiseikai Narashino Hospital, Narashino.
Research Center for Child Mental Development, Chiba University.
Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University.
Center for Forensic Mental Health, Chiba University.
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan.



Set-shifting (SS) difficulties and weak central coherence (CC) are commonly associated with autism spectrum disorders (ASD). Cognitive remediation therapy (CRT) aims to improve such cognitive processing; however, there are no reports on CRT for patients with ASD. This pilot study aimed to provide preliminary evidence to support the use of CRT for individuals with ASD and provide data to inform future studies.


Nineteen individuals with ASD were recruited and administered a series of neuropsychological and questionnaire measures to examine cognitive function and clinical outcomes such as anxiety and depression. Participants received CRT, and cognitive function and clinical variables were re-evaluated at postintervention and after 3 months.


The participants demonstrated significant improvement in CC and anxiety at postintervention, which was maintained at 3-month follow-up. Although SS scores had improved with a large effect size, this was not statistically significant.


CRT improved CC and anxiety scores for individuals with ASD, suggesting that CRT is an effective treatment for individuals with ASD.


autism spectrum disorders; central coherence; cognitive flexibility; cognitive remediation therapy

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center