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Neurosci Biobehav Rev. 2018 Jan;84:289-298. doi: 10.1016/j.neubiorev.2017.08.018. Epub 2017 Aug 30.

Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression.

Author information

1
Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.
2
The Center for Cognitive Medicine, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, 37212, USA; Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
3
The Center for Cognitive Medicine, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, 37212, USA; Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA. Electronic address: warren.d.taylor@vanderbilt.edu.

Abstract

Late-life depression is characterized by both lower mood and poor cognitive performance, symptoms that often do not fully respond to current antidepressant medications. Nicotinic acetylcholine receptor (nAChR) agonists such as nicotine may serve as a novel therapeutic approach for this population. Both preclinical and preliminary clinical studies suggest that nAChR agonists can improve depressive behavior in animal models and improve mood in depressed individuals. Substantial literature also supports that nAChR agonists benefit cognitive performance, particularly in older populations. These potential benefits may be mediated by the effects of nAChR stimulation on neural network function and connectivity. Functional neuroimaging studies detail effects of nAChR agonists on the default mode network, central-executive network, and salience network that may oppose or reverse network changes seen in depression. We propose that, given the existent literature and the clinical presentation of late-life depression, nicotine or other nAChR agonists may have unique therapeutic benefits in this population and that clinical trials examining nicotine effects on mood, cognition, and network dynamics in late-life depression are justified.

KEYWORDS:

Acetylcholine; Aging; Antidepressant; Attention; Cognition; Cognitive control; Cognitive impairment; Default mode network; Depression; Depressive disorder; Executive control; Experimental therapeutics; Geriatrics; Intrinsic network; Memory; Nicotine; Nicotinic receptor; Review

PMID:
28859996
PMCID:
PMC5729074
DOI:
10.1016/j.neubiorev.2017.08.018
[Indexed for MEDLINE]
Free PMC Article

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