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Biomed Pharmacother. 2017 Nov;95:317-323. doi: 10.1016/j.biopha.2017.08.081. Epub 2017 Sep 12.

Effect of zinc gluconate, sage oil on inflammatory patterns and hyperglycemia in zinc deficient diabetic rats.

Author information

1
Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: mmelseweidy@yahoo.com.
2
Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt. Electronic address: Abdelmoniemali@yahoo.com.
3
Department of Biochemistry, Faculty of Sciences, Zagazig University, Zagazig 44519, Egypt. Electronic address: Nabila.zein@yahoo.com.
4
Department of Biochemistry, Faculty of Sciences, Zagazig University, Zagazig 44519, Egypt. Electronic address: kateralnada@gmail.com.

Abstract

BACKGROUND:

The relationship between zinc homeostasis and pancreatic function had been established. In this study we aimed firstly to configure the inflammatory pattern and hyperglycemia in zinc deficient diabetic rats. Secondly to illustrate the effect of two selected agents namely Zinc gluconate and sage oil (Salvia Officinalis, family Lamiaceae).

METHODS:

Rats were fed on Zinc deficient diet, deionized water for 28days along with Zinc level check up at intervals to achieve zinc deficient state then rats were rendered diabetic through receiving one dose of alloxan monohydrate (120mg/kg) body weight, classified later into 5 subgroups.

RESULTS:

Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- α), interleukins-6 1 β, inflammatory8 (IFN ȣ), pancreatic 1L1-β along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). Histopathological results of pancreatic tissues showed a good correlation with the biochemical findings.

CONCLUSIONS:

Both sage oil and zinc gluconate induced an improvement in the glycemic and inflammatory states. This may be of value like the therapeutic agent for diabetes.

KEYWORDS:

Inflammatory markers; Salvia officinales; Type1 diabetes mellitus; Zinc deficiency; Zinc gluconate; Zinc transporter 8 (Znt8)

PMID:
28858729
DOI:
10.1016/j.biopha.2017.08.081
[Indexed for MEDLINE]

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