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Int Immunopharmacol. 2017 Nov;52:44-50. doi: 10.1016/j.intimp.2017.08.016. Epub 2017 Aug 31.

Focus on the therapeutic efficacy of 3BNC117 against HIV-1: In vitro studies, in vivo studies, clinical trials and challenges.

Author information

1
Hebei University of Engineering, Affiliated Hospital, College of Medicine, Handan 056002, PR China.
2
Hebei University of Engineering, Affiliated Hospital, College of Medicine, Handan 056002, PR China. Electronic address: jingzhangwang@hebeu.edu.cn.

Abstract

3BNC117, which was discovered in 2011, is a broadly neutralizing antibody (bNAb) and specifically neutralizes the human immunodeficiency virus type-1 (HIV-1) by targeting the CD4-binding site. This is the first comprehensive review that focuses on the role of 3BNC117 in the prevention of HIV-1 and acquired immune deficiency syndrome (AIDS). Briefly, 3BNC117 neutralizes many HIV/SHIV strains in vitro, blocks HIV-1 acquisition in animal models via a pre-exposure prophylaxis, alleviates HIV-1-associated viremia via a post-exposure therapeutic effect, prevents the establishment of latent HIV-1 reservoirs, and induces both humoral and cellular anti-HIV immune responses in vivo. The outcomes of Phase I and Phase IIa clinical trials in 2015 and 2016 showed the safety, tolerability, and therapeutic efficacy of 3BNC117 in HIV-1-infected human individuals. Nevertheless, anti-3BNC117 antibodies and HIV-1 strains resistant to 3BNC117 pose clinical challenges to immunotherapy with 3BNC117, so potential strategies for optimizing the potency of 3BNC117 are suggested here. Predictably, HIV-1 prevention and AIDS treatment will benefit from combinational immunotherapies with 3BNC117 and other pharmaceuticals (bNAbs, antiretroviral medicines, viral inducers, etc.) in the near future.

KEYWORDS:

3BNC117; Anti-HIV immune response; Broadly neutralizing antibody; Human immunodeficiency virus; Immunotherapy; Viremia

PMID:
28858725
DOI:
10.1016/j.intimp.2017.08.016
[Indexed for MEDLINE]

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