Format

Send to

Choose Destination
Neuron. 2017 Aug 30;95(5):1171-1180.e7. doi: 10.1016/j.neuron.2017.08.015.

The Spatiotemporal Organization of the Striatum Encodes Action Space.

Author information

1
Champalimaud Neuroscience Program, Champalimaud Foundation, Lisbon 1400-038, Portugal. Electronic address: andreas.klaus@neuro.fchampalimaud.org.
2
Champalimaud Neuroscience Program, Champalimaud Foundation, Lisbon 1400-038, Portugal.
3
Center for the Neural Basis of Cognition and Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Statistics, Columbia University, New York, NY 10027, USA.
4
Department of Statistics, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
5
Champalimaud Neuroscience Program, Champalimaud Foundation, Lisbon 1400-038, Portugal; Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address: rc3031@columbia.edu.

Abstract

Activity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper movement. However, little is known about the spatiotemporal organization of this activity. We investigated the spatiotemporal organization of SPN ensemble activity in mice during self-paced, natural movements using microendoscopic imaging. Activity in both pathways showed predominantly local but also some long-range correlations. Using a novel approach to cluster and quantify behaviors based on continuous accelerometer and video data, we found that SPN ensembles active during specific actions were spatially closer and more correlated overall. Furthermore, similarity between different actions corresponded to the similarity between SPN ensemble patterns, irrespective of movement speed. Consistently, the accuracy of decoding behavior from SPN ensemble patterns was directly related to the dissimilarity between behavioral clusters. These results identify a predominantly local, but not spatially compact, organization of direct- and indirect-pathway SPN activity that maps action space independently of movement speed.

KEYWORDS:

action space; basal ganglia; behavior decoding; calcium imaging; caudate; direct pathway; indirect pathway; neural correlation; population activity; putamen

PMID:
28858619
PMCID:
PMC5584673
DOI:
10.1016/j.neuron.2017.08.015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center