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J Psychopharmacol. 2017 Sep;31(9):1137-1148. doi: 10.1177/0269881117725711. Epub 2017 Aug 31.

Anti-inflammatory treatments for mood disorders: Systematic review and meta-analysis.

Author information

1
1 Camden and Islington NHS Foundation Trust, St Pancras Hospital, London, UK.
2
2 Centre for Affective Disorders, King's College London, London, UK.

Abstract

BACKGROUND:

Recent studies suggest that anti-inflammatory medication may play a role in the treatment of mood disorders.

AIMS:

The purpose of this study was to determine the efficacy of anti-inflammatory drugs in patients with major depressive disorder and bipolar disorder.

METHOD:

The Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PsychINFO and Clinicaltrials.gov were searched from inception until 15 April 2017 for completed and on-going randomized controlled trials of anti-inflammatory agents for major depressive disorder and bipolar disorder. Data from randomized controlled trials assessing the antidepressant and anti-manic effect of adjunctive mechanistically diverse anti-inflammatory agents were pooled to determine standard mean differences (SMDs) compared with placebo and/or treatment as usual.

RESULTS:

Patients receiving anti-inflammatory agents showed lower post-treatment depressive symptom scores compared with those receiving placebo with a standard mean difference of -0.71 (six randomized controlled trials, n=214, 95% CI -1.24 to -0.17, p=0.009). Anti-inflammatory treatment was found to reduce post-treatment manic symptom scores with a standard mean difference of -0.72 (three randomized controlled trials, n=96, 95% CI -1.31 to -0.13, p=0.02). Anti-inflammatories did not show a statistically significant improvement in the secondary outcome measure (change in symptom scores from baseline to outcome).

CONCLUSIONS:

Further high quality trials are needed before making recommendations for the routine clinical use of anti-inflammatories in the treatment of mood disorders.

KEYWORDS:

Depression; anti-inflammatory; bipolar disorder; inflammation

PMID:
28858537
DOI:
10.1177/0269881117725711
[Indexed for MEDLINE]

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