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Molecules. 2017 Aug 31;22(9). pii: E1447. doi: 10.3390/molecules22091447.

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Author information

1
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. ozmagic15@snu.ac.kr.
2
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. men0528@snu.ac.kr.
3
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. lbj@nmr.snu.ac.kr.

Abstract

Tuberculosis is an infectious disease caused by Mycobacteriumtuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy.

KEYWORDS:

Mycobacterium tuberculosis; antibiotic target; biomolecular interaction; nuclear magnetic resonance (NMR)

PMID:
28858250
PMCID:
PMC6151718
DOI:
10.3390/molecules22091447
[Indexed for MEDLINE]
Free PMC Article

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