Format

Send to

Choose Destination
Cancer Causes Control. 2017 Oct;28(10):1021-1026. doi: 10.1007/s10552-017-0948-1. Epub 2017 Aug 30.

Risk of depression, anxiety, and adjustment disorders in women with a suspected but unconfirmed diagnosis of breast or genital organ cancer in Germany.

Author information

1
Epidemiology, QuintilesIMS, Darmstädter Landstraße 108, 60598, Frankfurt am Main, Germany. kkostev@de.imshealth.com.
2
Department of Gynecology and Obstetrics, Philipps-University Marburg, Marburg, Germany. kkostev@de.imshealth.com.
3
Faculty of Medicine, University of Paris 5, Paris, France.
4
Department of Gynecology and Obstetrics, Philipps-University Marburg, Marburg, Germany.

Abstract

BACKGROUND:

Breast cancer (BC) and genital organ cancers (GOC) are known to have a major impact on the quality of life of patients. The aim of this study was to analyze the risk of depression, anxiety, and adjustment disorders in women in Germany with a suspected but unconfirmed diagnosis of BC or GOC in their medical history.

METHODS:

This study included women who received a suspected diagnosis of BC or GOC and were followed between 2007 and 2015 (index date). These women were matched (1:1:1) by age to women with a confirmed diagnosis of BC or GOC and women without a cancer diagnosis. The main outcome measure of the study was the rate of depression, anxiety, and adjustment disorder diagnoses within 3 years of the index date.

RESULTS:

The present analysis included a total of 4,842 patients (mean age = 49.3 years). Within 3 years of the index date, 23.5% of women with a confirmed diagnosis of BC or GOC, 14.1% of those with a suspected diagnosis of BC or GOC, and 10.5% of those without a cancer diagnosis developed depression, anxiety, or an adjustment disorder (log-rank p value <0.001). Women with a suspected diagnosis of cancer were at a higher risk for these psychiatric conditions than those without a cancer diagnosis (BC and GOC: HR 1.32; BC: HR 1.21; GOC: HR 1.50).

CONCLUSION:

A suspected diagnosis of BC or GOC in a woman's medical history is associated with an increased risk of developing depression, anxiety, and adjustment disorders.

KEYWORDS:

Adjustment disorders; Anxiety; Breast cancer; Depression; Genital organ cancers; Suspected cancer diagnosis

PMID:
28856543
DOI:
10.1007/s10552-017-0948-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center