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Sci Rep. 2017 Aug 30;7(1):9924. doi: 10.1038/s41598-017-10089-4.

Synchronized Activity in The Main and Accessory Olfactory Bulbs and Vomeronasal Amygdala Elicited by Chemical Signals in Freely Behaving Mice.

Author information

1
Department of de Biologia Cellular, Facultat de Ciències Biològiques, Universitat de València, Burjassot, Spain.
2
Laboratori de Circuits Neurals, Department of d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Valencia, Spain.
3
Unitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I. Castelló de la Plana, Castelló, Spain.
4
Laboratori de Circuits Neurals, Department of d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Valencia, Spain. vicent.teruel@uv.es.

Abstract

Chemosensory processing in mammals involves the olfactory and vomeronasal systems, but how the activity of both circuits is integrated is unknown. In our study, we recorded the electrophysiological activity in the olfactory bulbs and the vomeronasal amygdala in freely behaving mice exploring a battery of neutral and conspecific stimuli. The exploration of stimuli, including a neutral stimulus, induced synchronic activity in the olfactory bulbs characterized by a dominant theta rhythmicity, with specific theta-gamma coupling, distinguishing between vomeronasal and olfactory structures. The correlated activation of the bulbs suggests a coupling between the stimuli internalization in the nasal cavity and the vomeronasal pumping. In the amygdala, male stimuli are preferentially processed in the medial nucleus, whereas female cues induced a differential response in the posteromedial cortical amygdala. Thus, particular theta-gamma patterns in the olfactory network modulates the integration of chemosensory information in the amygdala, allowing the selection of an appropriate behaviour.

PMID:
28855563
PMCID:
PMC5577179
DOI:
10.1038/s41598-017-10089-4
[Indexed for MEDLINE]
Free PMC Article

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