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J Cell Biol. 2017 Nov 6;216(11):3497-3507. doi: 10.1083/jcb.201612100. Epub 2017 Aug 30.

lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy.

Author information

1
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA rneppl@bwh.harvard.edu.
2
Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
3
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA.
4
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA kxwalsh@bu.edu.

Abstract

Skeletal muscle exhibits remarkable plasticity in its ability to modulate its mass in response to the physiologic changes associated with functional use, systemic disease, and aging. Although a gradual loss of muscle mass normally occurs with advancing age, its increasingly rapid progression results in sarcopenia in a subset of individuals. The identities of muscle-enriched, long noncoding RNAs that regulate this process are unknown. Here, we identify a long noncoding RNA, named Chronos, whose expression in muscle is positively regulated with advancing age and negatively regulated during Akt1-mediated growth. Inhibition of Chronos induces myofiber hypertrophy both in vitro and in vivo, in part, through the epigenetic modulation of Bmp7 signaling.

PMID:
28855249
PMCID:
PMC5674882
DOI:
10.1083/jcb.201612100
[Indexed for MEDLINE]
Free PMC Article

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