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Genome Med. 2017 Aug 31;9(1):77. doi: 10.1186/s13073-017-0470-9.

Clinical implications of neoepitope landscapes for adult and pediatric cancers.

Feng YY1, Griffith OL2,3,4,5, Griffith M6,7,8,9.

Author information

1
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
2
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. obigriffith@wustl.edu.
3
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. obigriffith@wustl.edu.
4
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. obigriffith@wustl.edu.
5
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. obigriffith@wustl.edu.
6
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. mgriffit@wustl.edu.
7
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mgriffit@wustl.edu.
8
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. mgriffit@wustl.edu.
9
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. mgriffit@wustl.edu.

Abstract

Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers.See related research article 10.1186/s13073-017-0468-3.

KEYWORDS:

Exome sequencing; Immunotherapy; Neoepitope; Personalized cancer vaccine; RNA sequencing; Whole-genome sequencing

PMID:
28854952
PMCID:
PMC5577778
DOI:
10.1186/s13073-017-0470-9
[Indexed for MEDLINE]
Free PMC Article

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