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PLoS One. 2017 Aug 30;12(8):e0184122. doi: 10.1371/journal.pone.0184122. eCollection 2017.

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.

Author information

1
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
2
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
3
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
4
Department of Clinical Neurosciences, The University of Edinburgh, Edinburgh, United Kingdom.

Abstract

Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.

PMID:
28854284
PMCID:
PMC5576729
DOI:
10.1371/journal.pone.0184122
[Indexed for MEDLINE]
Free PMC Article

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