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PLoS One. 2017 Aug 30;12(8):e0184122. doi: 10.1371/journal.pone.0184122. eCollection 2017.

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.

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Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Neurosciences, The University of Edinburgh, Edinburgh, United Kingdom.


Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.

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