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PLoS One. 2017 Aug 30;12(8):e0182708. doi: 10.1371/journal.pone.0182708. eCollection 2017.

Non-alcoholic fatty liver disease as a risk factor for female sexual dysfunction in premenopausal women.

Lee JY1,2, Shin DW3,4,5, Oh JW1, Kim W6, Joo SK6, Jeon MJ1, Kim SM1,2,4, Yun JM3,4, Son KY3,4, Park JH3,4, Cho B3,4, Lee SM1,4.

Author information

1
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
3
Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
4
Health Promotion Center, Seoul National University Hospital, Seoul, Korea.
5
Department of Family Medicine, Samsung Medical Center, Seoul, Korea.
6
Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.

Abstract

OBJECTIVE:

Non-alcoholic fatty liver disease (NAFLD) has become a common and important chronic liver disease worldwide. Previous studies have indicated that NAFLD has an adverse effect on the quality of life, but information is lacking about the impact of NAFLD on female sexual dysfunction. The aim of this study was to determine the association between NAFLD and female sexual dysfunction in premenopausal women.

METHODS:

This retrospective study consisted of premenopausal women who were sexually active and visited the outpatient clinic for a routine health check-up between January 2010 and December 2011. Based on the examination of the liver ultrasound scan, the study population was divided into 2 groups: cases with NAFLD and normal controls (cases without NAFLD). The female sexual function was compared between the two groups of cases. For the assessment of sexual function, a female sexual function index (FSFI) questionnaire was used.

RESULTS:

Four hundred seventy women were included, and the prevalence of NAFLD and female sexual dysfunction were 67/470 (14.3%) and 238/470 (50.6%), respectively. Cases with NAFLD had a lower total FSFI score and higher rate of female sexual dysfunction than the normal control [median score of total FSFI (interquartile range): 24.7 (21.9-27.8) in NAFLD vs. 26.7 (23.7-29.8) in normal control, p<0.005; the female sexual dysfunction: 64.2% in NAFLD vs. 48.4% in normal control, p<0.05]. This difference in female sexual dysfunction between the two groups remained significant after adjustment.

CONCLUSION:

NAFLD is associated with female sexual dysfunction in premenopausal women.

PMID:
28854246
PMCID:
PMC5576732
DOI:
10.1371/journal.pone.0182708
[Indexed for MEDLINE]
Free PMC Article

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