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Bull Exp Biol Med. 2017 Aug;163(4):415-418. doi: 10.1007/s10517-017-3817-8. Epub 2017 Aug 29.

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

Author information

1
Department of Histology, Embryology and Cytology, Kursk, Russia.
2
Department of Histology, Embryology and Cytology, Kursk, Russia. bobig@mail.ru.
3
Department of Physiology, Research Institute of General Pathology, Kursk State Medical University, Kursk, Russia. bobig@mail.ru.
4
Department of Physiology, Research Institute of General Pathology, Kursk State Medical University, Kursk, Russia.
5
Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.

Abstract

We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver. Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate. Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity. Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum. The other parameters remained unchanged.

KEYWORDS:

Selank; free radical oxidation; liver; restraint stress; serum aminotransferases

PMID:
28853100
DOI:
10.1007/s10517-017-3817-8
[Indexed for MEDLINE]

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