Format

Send to

Choose Destination
Probiotics Antimicrob Proteins. 2018 Dec;10(4):740-747. doi: 10.1007/s12602-017-9320-8.

Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study.

Author information

1
Department of Microbiology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2
Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran.
3
Department of Microbiology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. s.taghinezhad@srbiau.ac.ir.
4
Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran. s.taghinezhad@srbiau.ac.ir.
5
Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran. keyvanlab@yahoo.com.
6
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. keyvanlab@yahoo.com.

Abstract

We performed a randomized double-blind controlled trial to compare the efficacy and safety of multistrain probiotic and acyclovir in women patients with recurrent genital herpes simplex virus type 2 (HSV-2) infections. Eighty-one patients enrolled in the study were being treated with multistrain Lactobacillus brevis one vaginal capsule every 12 h and oral acyclovir 400 mg twice daily for 6 months. Of 53 patients who completed both treatment courses, no important differences were identified between acyclovir and probiotic for the primary and secondary efficacy endpoint, resolution of episode (hazard ratio, 0.60; 95% CI, 0.3429 to 1.0663; P = 0.08), lesion healing time (hazard ratio, 0.57; 95% CI, 0.3034 to 1.0717, P = 0.08), viral shedding (hazard ratio, 0.54; 95% CI, 0.3027 to 0.9750, P = 0.04), and percentage of pain (hazard ratio, 0.48; 95% CI, 0.2708 to 0.8545, P = 0.01). The median time to first and second recurrence after treatment were 43 and 121 days in patients receiving acyclovir and 33 and 118 days in patients receiving probiotic (HR 2.61; 95% CI, 1.4427 to 4.7546, P = 0.001, and HR 0.62; 95% CI, 0.3500 to 1.1133, P = 0.1, respectively). No clinically important effects happened during the probiotic treatment but some of adverse events reported in patients taking acyclovir. Easy availability, low cost, and no side effect of L. brevis are valuable properties of probiotic therapy compared with acyclovir. Therefore, we concluded that multistrain L. brevis could play an important role in suppression of recurrent genital herpes simplex virus infection.

KEYWORDS:

Acyclovir; HSV-2; Lactobacillus brevis; Probiotic; Recurrence

PMID:
28852985
DOI:
10.1007/s12602-017-9320-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center