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Neural Regen Res. 2017 Jul;12(7):1024-1027. doi: 10.4103/1673-5374.211173.

BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing.

Author information

1
Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan.
2
Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi, Japan.
3
Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women's University, Hyogo, Japan.
4
Graduate School of Frontier Bioscience, Osaka University, Suita, Japan.

Abstract

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF polymorphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

KEYWORDS:

BDNF; growth factor; ischemia; neural stem cells; peptide

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