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Neural Regen Res. 2017 Jul;12(7):1024-1027. doi: 10.4103/1673-5374.211173.

BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing.

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Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan.
Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi, Japan.
Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women's University, Hyogo, Japan.
Graduate School of Frontier Bioscience, Osaka University, Suita, Japan.


Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF polymorphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.


BDNF; growth factor; ischemia; neural stem cells; peptide

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