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Alzheimers Res Ther. 2017 Aug 29;9(1):67. doi: 10.1186/s13195-017-0288-0.

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort.

Author information

1
Centre Inserm U1219, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux School of Public Health, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux cedex, France. carole.dufouil@inserm.fr.
2
CHU de Bordeaux, Pole de sante publique, F-33000, Bordeaux, France. carole.dufouil@inserm.fr.
3
Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127, Department of Neurology, AP-HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, F-75006, Paris, France.
4
Memory Resource and Research Centre of Toulouse, CHU de Toulouse, Hôpital La Grave-Casselardit, F-31000, Toulouse, France.
5
Memory Resource and Research Centre of Lille, CHRU de Lille, Hôpital Roger Salengro, F-59000, Lille, France.
6
University Lille, INSERM U1171, F-59000, Lille, France.
7
Memory Resource and Research Centre of Strasbourg/Colmar, Department of Geriatrics, laboratoire ICube UMR 7357, FMTS, Hôpitaux Universitaires de Strasbourg, F-67000, Strasbourg, France.
8
Memory Resource and Research Centre of Paris Nord, AP-HP, Groupe Hospitalier Saint-Louis Lariboisière Fernand Widal, F-75010, Paris, France.
9
Memory Resource and Research Centre of Paris Broca, AP-HP, Hôpital Broca, F-75013, Paris, France.
10
Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France.
11
Centre Inserm U1219, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux School of Public Health, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux cedex, France.
12
Memory Resource and Research Centre of Bordeaux, CHU de Bordeaux, Hôpital Pellegrin, F-33000, Bordeaux, France.
13
Memory Resource and Research Centre of Bordeaux, CHU de Bordeaux, Hôpital Xavier Arnozan, F-33000, Bordeaux, France.
14
Memory Resource and Research Centre of Montpellier, CHU de Montpellier, Hôpital Gui de Chauliac, F-34000, Montpellier, France.
15
Memory Resource and Research Centre of Marseille, CHU de Marseille, Hôpital La Timone, F-13000, Marseille, France.
16
Memory Resource and Research Centre of Angers, CHU d'Angers, F-49000, Angers, France.
17
Memory Resource and Research Centre of Lyon, Hospices Civils de Lyon, Hôpital des Charpennes, F-69000, Lyon, France.
18
Memory Resource and Research Centre of Nice, CHU de Nice, Institut Claude Pompidou, EA 7276 CoBTeK "Cognition Behaviour Technology", F-06100, Nice, France.
19
Memory Resource and Research Centre of Dijon, CHU Dijon Bourgogne, Hôpital du Bocage, Hôpital de Champmaillot, F-21000, Dijon, France.
20
Memory Resource and Research of Amiens, CHU Amiens Picardie, Hôpital Nord, F-80000, Amiens, France.
21
Memory Clinic, Hôpital Avicenne, AP-HP, Hôpitaux Universitaires Paris-Seine-Saint-Denis, F-93009, Bobigny, France.
22
Memory Resource and Research Centre of Saint-Etienne, CHU de Saint-Etienne, Hôpital Nord, F-42000, Saint-Etienne, France.
23
Memory Resource and Research Centre of Saint-Etienne, CHU de Saint-Etienne, Hôpital de la Charité, F-42000, Saint-Etienne, France.
24
Memory Resource and Research Centre of Rouen, Neurology Department, Rouen University Hospital, F-76031, Rouen, France.
25
Memory Resource and Research Centre of Nancy, CHU de Nancy, F-54000, Nancy, France.
26
Memory Resource and Research Centre of Toulouse, CHU de Toulouse, Hôpital Purpan, F-31000, Toulouse, France.
27
Memory Resource and Research Centre of Poitiers, CHU de Poitiers, Hôpital de La Milétrie, F-86000, Poitiers, France.
28
Memory Resource and Research Centre of Grenoble, CHU de Grenoble Alpes, Hôpital de la Tronche, F-38000, Grenoble, France.
29
Memory Resource and Research Centre of Center Region, CHRU de Tours, Hôpital Bretonneau, F-37000, Tours, France.
30
Memory Resource and Research Centre of Strasbourg/Colmar, Hôpitaux Civils de Colmar, F-68000, Colmar, France.
31
Inserm U-118, Strasbourg University, F-67000, Strasbourg, France.
32
Memory Resource and Research Centre of Nantes, CHU de Nantes, F-44000, Nantes, France.
33
Memory Resource and Research Centre of Clermont-Ferrand, CHU de Clermont-Ferrand, F-63000, Clermont-Ferrand, France.
34
Memory Resource and Research Centre of Brest, CHRU de Brest, F-29000, Brest, France.
35
Memory Resource and Research Centre of Besançon, CHU de Besançon, Hôpital Jean Minjoz, Hôpital Saint-Jacques, F-25000, Besançon, France.
36
Centre pour l'Acquisition et le Traitement des Images, NeuroSpin, I2BM, Commissariat à l'Energie Atomique, F-91400, Saclay, France.
37
Sorbonne Universités, UPMC Université Paris 06, Inserm, CNRS, Institut du cerveau et la moelle (ICM) - Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital, F-75013, Paris, France.
38
CHU de Bordeaux, Pole de sante publique, F-33000, Bordeaux, France.
39
Nuclear Medicine Department, Pitié-Salpêtrière University Hospital, AP-HP, F-75006, Paris, France.
40
Laboratoire d'Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, F-75006, Paris, France.
41
NeuroSpin, I2BM, Commissariat à l'Energie Atomique, Université Paris-Saclay, F-91400, Saclay, France.

Abstract

BACKGROUND:

The natural history and disease mechanisms of Alzheimer's disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements.

METHODS:

In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] <1). Baseline data collection included neurological and physical examinations as well as extensive neuropsychological testing. To be included in the MEMENTO cohort, participants had to agree to undergo both brain magnetic resonance imaging (MRI) and blood sampling. Cerebral 18F-fluorodeoxyglucose positon emission tomography and lumbar puncture were optional. Automated analyses of cerebral MRI included assessments of volumes of whole-brain, hippocampal and white matter lesions.

RESULTS:

The 2323 participants, recruited from April 2011 to June 2014, were aged 71 years, on average (SD 8.7), and 62% were women. CDR was 0 in 40% of participants, and 30% carried at least one apolipoprotein E ε4 allele. We observed that more than half (52%) of participants had amnestic mild cognitive impairment (17% single-domain aMCI), 32% had non-amnestic mild cognitive impairment (16.9% single-domain naMCI) and 16% had isolated SCCs. Multivariable analyses of neuroimaging markers associations with cognitive categories showed that participants with aMCI had worse levels of imaging biomarkers than the others, whereas participants with naMCI had markers at intermediate levels between SCC and aMCI. The burden of white matter lesions tended to be larger in participants with aMCI. Independently of CDR, all neuroimaging and neuropsychological markers worsened with age, whereas differences were not consistent according to sex.

CONCLUSIONS:

MEMENTO is a large cohort with extensive clinical, neuropsychological and neuroimaging data and represents a platform for studying the natural history of ADRD in a large group of participants with different subtypes of MCI (amnestic or not amnestic) or isolated SCCs.

TRIAL REGISTRATION:

Clinicaltrials.gov, NCT01926249 . Registered on 16 August 2013.

KEYWORDS:

Alzheimer’s disease; Cognitive aging; Cohort studies; Natural history studies (prognosis); Neuroimaging

PMID:
28851447
PMCID:
PMC5576287
DOI:
10.1186/s13195-017-0288-0
[Indexed for MEDLINE]
Free PMC Article

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