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Environ Toxicol Pharmacol. 2017 Oct;55:165-174. doi: 10.1016/j.etap.2017.08.017. Epub 2017 Aug 24.

Imidacloprid insecticide exposure induces stress and disrupts glucose homeostasis in male rats.

Author information

1
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. Electronic address: dr_samahkhalil@yahoo.com.
2
Animal Wealth Development Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
3
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
4
Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Abstract

In the present study, we evaluated the stress response in adult rats who were administered imidacloprid (IMI) orally in two doses (0.5 and 1.0mg/kg bw for 60days). It led to an alteration in the levels of cortisone and catecholamines and induced behavioral deficits, particularly in the animals exposed to the dose of 1.0mg/kg. IMI was further analyzed for the effect on glucose homeostasis in developing and adult rats at a dose of 1.0mg/kg bw where it elicited a hyperglycemic effect. Moreover, we observed an alteration in the mRNA levels of glucose transporters. Histopathological and immunohistochemical data displayed structural perturbations in pancreatic tissue with a decline in the expression of insulin and GLUT4, particularly in the developing rats. Collectively, IMI treatment resulted in stress represented by behavioral and biochemical changes, particularly at a dose of 1.0mg/kg bw. Moreover, IMI perturbed the glucose regulation through hyperglycemic activity in both developing and adult rats, an observation clearly evident in the developing rats.

KEYWORDS:

Forced swim test; Glucose transporter; Imidacloprid; Neonicotinoid; Open field test

PMID:
28850943
DOI:
10.1016/j.etap.2017.08.017
[Indexed for MEDLINE]

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