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Biomaterials. 2017 Nov;145:72-80. doi: 10.1016/j.biomaterials.2017.08.034. Epub 2017 Aug 19.

Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials.

Author information

1
Univ. Bordeaux, ARNA Laboratory, F-33016 Bordeaux, France; INSERM U1212, CNRS UMR 5320, ARNA Laboratory, F-33016 Bordeaux, France.
2
INSERM, U1226, Biotis Laboratory, F-33016 Bordeaux, France.
3
Univ. Bordeaux, ARNA Laboratory, F-33016 Bordeaux, France; INSERM U1212, CNRS UMR 5320, ARNA Laboratory, F-33016 Bordeaux, France. Electronic address: philippe.barthelemy@inserm.fr.

Abstract

There is a critical need for soft materials in the field of regenerative medicine and tissue engineering. However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications. Here we use a bottom-up approach for synthesizing supramolecular gels to generate novel biomaterial candidates. We evaluated the low molecular weight gels candidates in vivo and identified one urea-containing molecule, compound 16, that avoid foreign body reactions in mice. The self-assembly of bolaamphiphiles creates a unique hydrogel supramolecular structures featuring fast gelation kinetics, high elastic moduli, thixotropic, and thermal reversibility properties. This soft material, which inhibits recognition by macrophages and fibrous deposition, exhibits long-term stability after in vivo injection.

KEYWORDS:

Biomaterials; Bolaamphiphiles; Low molecular weight hydrogelator; Rheology; Subcutaneous implantation; Supramolecular structures

[Indexed for MEDLINE]

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