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Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700281. Epub 2018 Jan 8.

Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway.

Author information

1
Institute of Natural Medicinal Chemistry and Green Chemistry, College of Light Industry and Chemical Engineering, Guangdong University of Technology, Guangzhou, 510006, China.
2
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
3
Infinitus (China) Company Ltd, Guangzhou, 510006, China.
4
Allan Conney Biotechnology Company Ltd, Foshan, 528200, China.
5
Wuyi University, Jiangmen, 529020, China.

Abstract

SCOPE:

Curcuma longa (turmeric) is a folk medicine in South and Southeast Asia, which has been widely used to alleviate chronic inflammation. Aromatic-turmerone is one of the main components abundant in turmeric essential oil. However, little information is available from controlled studies regarding its biological activities and underlying molecular mechanisms against chronic inflammation in the brain. In the current study, we employed a classical LPS model to study the effect and mechanism of aromatic-turmerone on neuroinflammation.

METHODS AND RESULTS:

The effects of aromatic-turmerone were studied in LPS-treated mice and BV2 cells. The cognitive function assays, protein analyses, and histological examination were performed. Oral administration of aromatic-turmerone could reverse LPS-induced memory disturbance and normalize glucose intake and metabolism in the brains of mice. Moreover, aromatic-turmerone significantly limited brain damage, through inhibiting the activation of microglia and generation of inflammatory cytokines. Further study in vitro revealed that aromatic-turmerone targeted Toll-like receptor 4 mediated downstream signaling, and lowered the release of inflammatory mediators.

CONCLUSION:

These observations indicate that aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation and may be useful in the treatment of neuronal inflammatory diseases.

KEYWORDS:

Aromatic-turmerone; LPS; Memory impairments; Neuroinflammation; Toll-like receptor

PMID:
28849618
DOI:
10.1002/mnfr.201700281
[Indexed for MEDLINE]

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