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Adv Exp Med Biol. 2017;975 Pt 2:1011-1020. doi: 10.1007/978-94-024-1079-2_80.

Taurine Intake with Magnesium Reduces Cardiometabolic Risks.

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, 4-16, Edagawa Town, Hyogo Pref., Nishinomiya City, 663-8143, Japan.
Laboratory of Preventive Nutritional Medicine, Research Institute for Production and Development, 15, Shimogamo Morimotocho, Sakyoku, Kyoto City, 606-8413, Japan.
Hyogo Prefecture Health Promotion Association, 2-1-12, Aratacho, Hyogo-ku, Kobe City, 652-0032, Japan.
, 4-16, Edagawa Town, Hyogo Pref., Nishinomiya City, 663-8143, Japan.


WHO-CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study revealed the quintile analyses of 24-h urinary (24 U) taurine (T) and magnesium (Mg) excretions were inversely related with cardiometabolic risks (CMR) such as obesity, hypertension and hypercholesterolemia in 50 population samples in the world. To exclude the influence of ethnicity in the study, 24 U T and Mg excretions were analyzed for the association with CMR in one ethnicity, Japanese population.24 U T/creatinine (C) ratios were divided into 5 quintiles and the ratios of Japanese to the total of each quintile were analyzed from CARDIAC Study samples. The highest 24 U T quintile consisted of 60% Japanese, indicating high seafood consumption in Japanese.Over 600 Japanese aged 30-79 were invited to a health examination for blood pressure measurement and for fasting blood and 24 U samplings. Tertile analysis of 24 U T/C ratios in relation to CMR indicated the third tertile had significantly higher HDL cholesterol, 24 U potassium (K) and 24 U salt than the first (lowest) tertile. Tertile analysis of 24 U Mg/C ratios indicated the third tertile had significantly lower body mass index and significantly higher folic acid, 24 U isoflavones, K and salt than the first tertile after age and gender adjustment. The third tertile of both T/C and Mg/C had significantly lower body mass index, LDL/HDL and Na/K ratios, and significantly higher HDL cholesterol and folic acid than the first tertile, indicating seafood eaters taking Mg rich diets had lower risks of obesity, atherosclerosis, hypertension and higher folic acid, beneficial for healthy longevity.


24-h urine; Atherogenic index; Blood pressure; Body mass index; Folic acid; HDL cholesterol; Magnesium; Potassium; Salt; Taurine

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