Format

Send to

Choose Destination
Adv Exp Med Biol. 2017;975 Pt 2:943-953. doi: 10.1007/978-94-024-1079-2_75.

Anti-inflammatory Effects of Galactose-Taurine Sodium Salt in LPS-Activated RAW 264.7 Cells.

Author information

1
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea.
2
Department of Food and Nutrition, Inha University, Incheon, Republic of Korea.
3
Department of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea.
4
Department of Marine Life Science, Jeju National University, Jeju, Republic of Korea.
5
Jeju International Marine Science Center for Research and Education, Korea Institute of Ocean Science and Technology (KIOST), Jeju, Republic of Korea.
6
Department of Chemistry, Konkuk University, Seoul, Republic of Korea.
7
Division of Food and Nutrition, Chonnam National University, Gwang ju, Republic of Korea.
8
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea. sunny3843@jnu.ac.kr.
9
Department of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea. sunny3843@jnu.ac.kr.
10
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea. gnahn@jnu.ac.kr.
11
Department of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea. gnahn@jnu.ac.kr.

Abstract

In this study, we synthesized Galactose-Taurine sodium salt (G-T) as a functional food ingredient to enhance biological activities of taurine. Also, anti-inflammatory effects of G-T were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. G-T found to reduce the generations of the LPS-stimulated nitric oxide (NO) and prostaglandin E2 (PGE2) via down-regulating the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Also, G-T reduced the secretion of inflammatory cytokines including interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF-α) in LPS-treated RAW 264.7 cells. Finally, we identified that G-T inhibits the activation of nuclear factor-κB (NF-κB) and the phosphorylation of inhibitor κB (IκB)-α. From these results, this study first suggests that G-T could be considered as an effective anti-inflammatory agent.

KEYWORDS:

Anti-inflammatory; Galactose-taurine sodium salt; LPS

PMID:
28849513
DOI:
10.1007/978-94-024-1079-2_75
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center