Format

Send to

Choose Destination
J Hepatocell Carcinoma. 2017 Aug 7;4:111-121. doi: 10.2147/JHC.S136652. eCollection 2017.

A Phase I trial using local regional treatment, nonlethal irradiation, intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect.

Author information

1
Department of Surgery, St Joseph's Regional Medical Center, Paterson.
2
Department of Surgery, Rutgers New Jersey Medical School-University Hospital.
3
Department of Interventional Radiology, Rutgers New Jersey Medical School-University Hospital.
4
Department of Radiation Oncology, Beth Israel Medical Center, Newark.
5
Department of Radiation Oncology, Clara Maas Hospital, Belleville, NJ.
6
Oncovir, Washington, DC, USA.

Abstract

PURPOSE:

To determine the safety of an approach to immunologically enhance local treatment of hepatocellular cancer (HCC) by combining nonlethal radiation, local regional therapy with intratumoral injection, and systemic administration of a potent Toll-like receptor (TLR) immune adjuvant.

METHODS:

Patients with HCC not eligible for liver transplant or surgery were subject to: 1) 3 fractions of 2-Gy focal nonlethal radiation to increase tumor antigen expression, 2) intra-/peri-tumoral (IT) injection of the TLR3 agonist, polyinosinic-polycytidylic acid polylysine carboxymethylcellulose (poly-ICLC), to induce an immunologic "danger" response in the tumor microenvironment with local regional therapy, and 3) systemic boosting of immunity with intramuscular poly-ICLC. Primary end points were safety and tolerability; secondary end points were progression-free survival (PFS) and overall survival (OS) at 6 months, 1 year, and 2 years.

RESULTS:

Eighteen patients with HCC not eligible for surgery or liver transplant were treated. Aside from 1 embolization-related severe adverse event, all events were ≤grade II. PFS was 66% at 6 months, 39% at 12 months, and 28% at 24 months. Overall 1-year survival was 69%, and 2-year survival 38%. In patients <60 years old, 2-year survival was 62.5% vs. 11.1% in patients aged >60 years (P<0.05). Several patients had prolonged PFS and OS.

CONCLUSION:

Intra-tumoral injection of the TLR3 agonist poly-ICLC in patients with HCC is safe and tolerable when combined with local nonlethal radiation and local regional treatment. Further work is in progress to evaluate if this approach improves survival compared to local regional treatment alone and characterize changes in anticancer immunity.

KEYWORDS:

Toll-like receptor; autologous vaccine; human trial; immunotherapy; liver cancer

Conflict of interest statement

Disclosure AMS is an employee of Oncovir and owns stock in the company. The other authors have no conflicts of interests in this work and not made any financial investment, nor have received direct funds from Oncovir Pharmaceutical.

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center