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Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01056-17. doi: 10.1128/AAC.01056-17. Print 2017 Nov.

In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris.

Author information

1
Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
2
Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
3
Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
4
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
5
Université Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France.
6
Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
7
Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
8
Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran badalii@yahoo.com.
9
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

We determined the in vitro interactions between echinocandins and azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.

KEYWORDS:

Candida auris; azoles; echinocandins; in vitro interactions

PMID:
28848002
PMCID:
PMC5655075
DOI:
10.1128/AAC.01056-17
[Indexed for MEDLINE]
Free PMC Article

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