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Neurosci Biobehav Rev. 2018 Jan;84:325-336. doi: 10.1016/j.neubiorev.2017.08.014. Epub 2017 Aug 25.

Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis.

Author information

1
University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Hanzeplein 1, 9713GZ Groningen, The Netherlands. Electronic address: i.h.ruisch@umcg.nl.
2
University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Hanzeplein 1, 9713GZ Groningen, The Netherlands. Electronic address: a.dietrich@accare.nl.
3
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, The Netherlands. Electronic address: j.glennon@donders.ru.nl.
4
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, 6525 GC Nijmegen, The Netherlands. Electronic address: jan.buitelaar@radboudumc.nl.
5
University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Hanzeplein 1, 9713GZ Groningen, The Netherlands. Electronic address: p.hoekstra@accare.nl.

Abstract

We conducted meta-analyses of relationships between highly prevalent substance use during pregnancy and offspring conduct disorder problems. In total 36 studies were included. Odds ratios (ORs) were 2.06 (1.67-2.54, 25 studies) for maternal smoking, 2.11 (1.42-3.15, 9 studies) for alcohol use, and 1.29 (0.93-1.81, 3 studies) for cannabis use, while a single study of caffeine use reported no effects. Our meta-analyses support an association between smoking and alcohol use during pregnancy, and offspring conduct problems, yet do not resolve causality issues given potential confounding by genetic factors, gene-environment interactions, and comorbidity such as with attention deficit hyperactivity disorders. Future studies should use genetically sensitive designs to investigate the role of pregnancy substance use in offspring conduct problems and may consider more broadly defined behavioral problems.

KEYWORDS:

Alcohol; Caffeine; Cannabis; Conduct disorder; Conduct problems; Meta-analysis; Pregnancy; Prenatal environment; Smoking

PMID:
28847489
DOI:
10.1016/j.neubiorev.2017.08.014
[Indexed for MEDLINE]

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