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EuroIntervention. 2017 Aug 29. pii: EIJ-D-17-00434. doi: 10.4244/EIJ-D-17-00434. [Epub ahead of print]

Final five-year outcomes after implantation of biodegradable polymer-coated biolimus-eluting stents versus durable polymer-coated sirolimus-eluting stents.

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1
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Abstract

AIMS:

To report long-term safety and efficacy of the biodegradable polymer-coated biolimus-eluting Nobori stent compared to the durable polymer-coated sirolimus-eluting Cypher stent.

METHODS AND RESULTS:

SORT OUT V randomized 2,468 patients 1:1 to the Nobori (n=1,229) versus the Cypher stent (n=1,239). Clinically driven event detection based on Danish registries was used. The primary endpoint was a composite of safety (cardiac death, myocardial infarction, definite stent thrombosis) and efficacy (target vessel revascularization). Individual components of the primary endpoint comprise the secondary endpoints. At 5-year follow-up the composite endpoint rate was found to be similar in patients treated with the two study stents (Nobori 182/1,229 [14.8%] vs. Cypher 197/1,239 [15.8%]; odds ratio [OR] 0.93, 95% CI 0.75-1.16; p=0.53). Rates of definite stent thrombosis was also found to be similar in patients treated with the two study stents (Nobori 23/1229 [1.9%] vs. Cypher 18/1,239 [1.5%]; [OR] 1.31, 95% CI 0.70-2.47; p=0.40) as was the other secondary endpoints.

CONCLUSIONS:

At 5-year follow-up, the Nobori stent with a biodegradable polymer coating provided similar safety and efficacy profile when compared to the durable polymer first generation Cypher stent.

PMID:
28846543
DOI:
10.4244/EIJ-D-17-00434
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